Human IL-1 beta Recombinant Protein
Human IL-1 beta Recombinant Protein (Cat. No. 200-01B-50UG)은 PeproTech에서 제공하는 Recombinant Human Interleukin-1 beta (IL-1β) 단백질입니다.
본 제품은 E. coli expression system을 통해 생산된 recombinant protein으로, 153 amino acids로 구성된 약 17.3 kDa의 단백질입니다. SDS-PAGE 및 HPLC 기준 ≥98% purity가 확인되었으며, endotoxin concentration은 <1 EU/µg입니다
Human IL-1 beta Recombinant Protein은 Functional Assay, ELISA, Western Blot 및 in vitro 연구 등 다양한 연구 목적으로 활용할 수 있습니다.
* 모든 제품은 부가세가 포함된 금액입니다.
＊재고 문의 T.031-723-7979 / E. info@cellto.co.kr / 카카오플러스 셀투바이오
200-01B-1MG will be provided as 2 x 500 µg (200-01B-500UG).
Recombinant Human IL-1beta is a 17.3 kDa protein containing 153 amino acid residues.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
* 모든 제품은 부가세가 포함된 금액입니다.
＊재고 문의 T.031-723-7979 / E. info@cellto.co.kr / 카카오플러스 셀투바이오
200-01B-1MG will be provided as 2 x 500 µg (200-01B-500UG).
Recombinant Human IL-1beta is a 17.3 kDa protein containing 153 amino acid residues.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
